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|
Plasma ratio
|
Platform
|
Group
|
Cut-off
|
Sensitivity, %
|
Specificity, %
|
PPV, %
|
NPV, %
|
|---|
|
Age, APOE-ε4
| |
Total
|
na
|
84 (69–94)
|
46 (38–54)
|
27 (23–31)
|
93 (85–96)
|
|
CN
|
na
|
67 (45–84)
|
65 (56–73)
|
25 (19–33)
|
92 (86–95)
|
|
aMCI
|
na
|
79 (49–95)
|
67 (45–84)
|
58 (43–72)
|
84 (65–94)
|
|
Aβ1–42/Aβ1–40
|
ELISA
|
Total
|
< 0.159
|
78 (62–90)
|
75 (68–82)
|
42 (34–50)
|
93 (88–96)
|
|
CN
|
< 0.159
|
78 (56–93)
|
81 (74–87)
|
41 (32–51)
|
96 (91–98)
|
|
aMCI
|
< 0.170
|
86 (57–98)
|
67 (45–84)
|
60 (45–73)
|
89 (68–97)
|
|
SIMOA
|
Total
|
< 0.230
|
74 (57–87)
|
80 (72–86)
|
46 (37–55)
|
93 (88–96)
|
|
CN
|
< 0.229
|
70 (47–87)
|
79 (71–86)
|
36 (27–46)
|
94 (89–97)
|
|
aMCI
|
< 0.226
|
79 (49–95)
|
88 (68–97)
|
79 (55–92)
|
88 (71–95)
|
|
Aβ1–42/t-tau
|
ELISA
|
Total
|
< 1.19
|
84 (68–94)
|
64 (56–71)
|
35 (30–41)
|
95 (89–97)
|
|
CN
|
< 1.12
|
78 (56–93)
|
69 (60–76)
|
30 (23–37)
|
96 (90–98)
|
|
aMCI
|
< 1.18
|
93 (66–100)
|
79 (58–93)
|
72 (54–85)
|
95 (74–99)
|
|
SIMOA
|
Total
|
< 0.862
|
79 (63–90)
|
68 (60–75)
|
36 (30–43)
|
93 (88–96)
|
|
CN
|
< 0.899
|
83 (61–95)
|
63 (54–71)
|
27 (22–33)
|
96 (90–99)
|
|
aMCI
|
< 0.815
|
79 (49–95)
|
88 (68–97)
|
79 (55–92)
|
88 (71–95)
|
- aMCI amnestic mild cognitive impairment, Aβ β-amyloid, CN cognitively normal, NPV negative predictive value, PPV positive predictive value, t-tau total tau
