Fig. 3

CLR01 protects P301S-tau mice from a disinhibition-like behavior. P301S-tau and wild-type littermate mice were examined using the open-field test for 5 min on days 1 and 35 of the treatment and the number of freezing episodes was recorded manually by a blinded operator. The data are presented as mean ± SD. P values were calculated using a mixed-effect, repeated-measure model with post hoc Sidak test