ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study

Table 2 Estimates of the fixed and random parts of the models with random effect on the intercept, using MMSE score values on follow-up as the dependent variable

	Model 1			Model 2			Model 3
Fixed effects	Estimate	SE	p	Estimate	SE	p	Estimate	SE	p
Intercept	24.09	0.38	< 0.001	37.73	2.33	< 0.001	10.19	1.73	< 0.001
Age, years	–	–	–	− 0.20	0.03	< 0.001	− 0.11	0.01	< 0.001
Male sex	–	–	–	0.94	0.46	0.04	0.18	0.25	0.4
Baseline altered MMSE	− 5.04	0.54	< 0.001	− 4.79	0.49	< 0.001	0.60	0.35	0.08
ADAM10, ng/mL	− 0.2	0.1	0.03	− 0.2	0.1	0.02	− 0.2	0.07	0.003
Baseline MMSE score	–	–	–	–	–	–	0.90	0.03	< 0.001
Random effects	Variance	SD		Variance	SD		Variance	SD
Individuals (intercept)	9.38	3.06		7.21	2.69		0.0	0.0
Residuals	7.01	2.65		7.01	2.65		6.02	2.45
Bayesian information criterion	2175			2148			1871

ISSN: 1758-9193