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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study

Fig. 6

PACC captures cognitive decline in carriers near expected symptom onset. Top, longitudinal trajectories of Preclinical Alzheimer’s Cognitive Composite (PACC) score by a age, b neocortical (Neo.) Aβ burden, and c precuneus (PC) tau. Arrowheads in b, c indicate most recent time point; lines are color-encoded by PSEN1-E280a carrier and clinical status according to the inset legend at top-right. Bottom, Relationships between annualized change in PACC and d age, e neo. Aβ change rate, and f PC tau change rate. Inset text gives Spearman correlation and p value within carriers. PACC change rate showed negative but non-significant associations with age and PC tau change rate, and no association with neo. Aβ change rate

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Alzheimer's Research & Therapy

ISSN: 1758-9193