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Characteristics
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CN (n = 29)
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SCD (n = 58)
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MCI (n = 29)
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AD (n = 23)
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P value
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|---|
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Age, median (95% CI), y
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63.0 (58–67)
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66.5 (63–69)
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72.0 (66–76) a,b
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71 (67–79) a,b
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< 0.001
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Education, median (95% CI), y
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12 (9–16)
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6 (6–9) a
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10 (6–12)
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6 (6–9) a,c
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< 0.001
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Gender (M:F)
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10: 19
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29:29
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21:8
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6:17
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< 0.004†
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MMSE, median (95% CI)
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29 (28–29)
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26 (25–27) a
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24 (21–26) a
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16 (15–19) a,b,c
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< 0.001
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SMCQ, median (95% CI)
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1 (1–2)
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5 (4–6) a
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5 (3–7) a
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8 (5–12) a,b
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< 0.001
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SBT, median (95% CI)
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0 (0–2)
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4 (2–4) a
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7 (4–11) a
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18 (17–22) a,b,c
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< 0.001
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CERAD, mean Z, median (95% CI)
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0.48 (0.42–0.61)
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0.14 (0.01–0.23)
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−0.81 (− 1.13 – − 0.33) a,b
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−1.65 (− 2.02 – − 0.94) a,b
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< 0.001
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BDS-ADL, median (95% CI)
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0 (0–0)
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0 (0–0.5) a
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0 (0–1) a
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2.5 (1–4.5) a,b,c
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< 0.001
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ESS, median (95% CI)
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5 (4–7)
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4 (4–5)
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3 (1–4)
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2 (1–5)
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0.0127
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CDR 0:0.5:1
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29:0:0
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58:0:0
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0:29:0
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0:8:15
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< 0.001†
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CDR-SB, median (95% CI)
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0 (0–0)
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0 (0–0)
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0.5 (0.5–1.0) a,b
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5 (3.5–6.0) a,b
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< 0.001
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GDS, median (95% CI)
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5 (3–8)
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8 (7–12) a
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9 (5–15)
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12 (7–20) a
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0.003
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Aβ PET(+), % (−:+)
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7.1 (26:2)
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21.1 (41:11)
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37.0 (17:10)
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76.2 (5:16)
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< 0.001†
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ApoE ε4 carrier, % (−:+)
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17.2 (24:5)
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20.7 (46:12)
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20.7 (23:6)
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56.5 (10:13)
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0.008†
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- MMSE Mini-Mental State Examination, SMCQ Subjective Memory Complaint Questionnaire, SBT Short Blessed Test, CERAD Consortium to Establish a Registry for AD, BDS-ADL Blessed Dementia Scale-Activities of Daily Living, ESS Epworth Sleepiness Scale, CDR Clinical Dementia Rating scale, CDR-SB CDR-Sum of Boxes, GDS Geriatric Depression Scale, ApoE apolipoprotein E
- aP < 0.05 versus CN; bP < 0.05 versus SCD; cP < 0.05 versus MCI by Dunn’s multiple comparison following the Kruskal–Wallis test
- †Chi-square test
