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Groups
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CSF biomarker levels, median (95% CI)
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|---|
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Aβ42
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Aβ40
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T-tau
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P-tau
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T-tau/Aβ42
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P-tau/Aβ42
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Aβ42/Aβ40
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|---|
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Luminex-AlzBio3
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|
CN
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573.2 (511.3–600.6)
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n.d.
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46.1 (42.1–55.4)
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16.1 (13.7–18.6)
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0.09 (0.08–0.10)
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0.03 (0.03–0.03)
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n.d.
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|
SCD
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520.3 (484.2–570.5)
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n.d.
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46.0 (41.4–55.6)
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16.9 (14.0–20.1)
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0.09 (0.08–0.11)
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0.03 (0.03–0.04)
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n.d.
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|
MCI
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411.2 a,b (282.8–541.1)
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n.d.
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48.4 (42.0–63.0)
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21.2 (15.1–25.5)
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0.12 (0.08–0.18)
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0.05 a (0.03–0.08)
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n.d.
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|
AD
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258.9 a,b,c (234.0–305.0)
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n.d.
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81.6 a,b,c (67.4–127.2)
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32.5 a,b (28.9–51.5)
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0.36 a,b,c (0.24–0.57)
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0.14 a,b,c (0.12–0.22)
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n.d.
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|
INNOTEST
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|
CN
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756.7 (583.8–879.8)
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6724 (5160–9070)
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195.0 (156.1–239.7)
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38.5 (35.0–49.7)
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0.26 (0.23–0.32)
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0.05 (0.05–0.07)
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0.11 (0.09–0.12)
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|
SCD
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794.9 (642.0–950.7)
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7405 (6388–9565)
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199.5 (145.6–270.4)
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43.8 (34.6–50.1)
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0.26 (0.20–0.31)
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0.05 (0.04–0.06)
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0.10 (0.09–0.12)
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|
MCI
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565.1 b (390.4–734.9)
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7158 (5551–8164)
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207.7 (156.3–291.5)
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46.4 (34.1–53.6)
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0.31 (0.23–0.66)
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0.07 (0.05–0.12)
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0.09 (0.06–0.12)
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|
AD
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407.5 a,b,c (328.1–412.0)
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6504 (5664–8218)
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548.0 a,b,c (389.4–832.0)
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72.5 a,b,c (56.9–113.8)
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1.55 a,b,c (0.95–2.71)
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0.24 a,b,c (0.14–0.38)
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0.05 a,b,c (0.05–0.07)
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|
Lumipulse
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|
CN
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1104 (850.2–1340)
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12,521 (10583–14,851)
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224.0 (176.0–254.8)
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28.7 (22.9–33.5)
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0.20 (0.16–0.24)
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0.03 (0.02–0.03)
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0.09 (0.08–0.09)
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|
SCD
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958.9 (763.9–1148)
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12,098 (10655–13,956)
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221.5 (174.8–284.5)
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28.3 (25.0–37.6)
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0.21 (0.17–0.27)
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0.03 (0.03–0.03)
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0.09 (0.08–0.09)
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|
MCI
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651.4 a,b (465.1–884.6)
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10,686 (9385–12,829)
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253.0 (192.0–342.0)
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35.0 (24.7–52.1)
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0.29 a (0.22–0.83)
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0.04 a,b (0.03–0.12)
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0.07 a,b (0.04–0.09)
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|
AD
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497.9 a,b (407.6–527.7)
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11,735 (9603–12,385)
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544.0 a,b,c (448.0–735.8)
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89.8 a,b,c (66.3–115.7)
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1.35 a,b,c (4.03–1.63)
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0.22 a,b,c (0.15–0.26)
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0.04 a,b,c (0.04–0.05)
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- aP < 0.05 versus CN; bP < 0.05 versus SCD; cP < 0.05 versus MCI by Dunn’s multiple comparison following Kruskal–Wallis test
