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Clinical variables
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Biomarkers
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Aβ42
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T-tau
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P-tau
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Aβ42/Aβ40
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t-tau/Aβ42
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p-tau/Aβ42
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F, P value
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CDR
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4.139, 0.008
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1.512, 0.215
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1.127, 0.341
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3.627, 0.015
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2.831, 0.041
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3.639, 0.015
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CDR-SB
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8.308, 0.0001
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1.584, 0.197
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1.011, 0.390
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5.982, 0.001
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4.472, 0.005
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6.416, 0.0001
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BDS-ADL
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3.471, 0.018
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1.634, 0.185
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0.749, 0.525
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2.975, 0.034
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2.199, 0.092
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3.095, 0.030
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SBT
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1.566, 0.201
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1.500, 0.218
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0.661, 0.578
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2.002, 0.117
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2.365, 0.074
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1.720, 0.167
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MMSE
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3.434, 0.020
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2.362, 0.076
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1.358, 0.260
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4.227, 0.007
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4.277, 0.007
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5.030, 0.003
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Constructional praxis
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2.921, 0.038
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1.596, 0.195
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0.335, 0.800
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2.071, 0.109
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2.244, 0.088
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2.088, 0.107
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Clock drawing
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3.295, 0.024
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3.482, 0.019
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1.356, 0.261
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4.751, 0.004
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5.091, 0.003
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5.034, 0.003
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- Ten subjects with AD-like CSF signature (2, 1, and 7 at first, second, and third follow-ups, respectively) and 9 subjects with normal CSF signature (1, 4, and 4 at third, second, and first follow-ups, respectively) were lost to follow-up. Numbers in bold indicate the variables with significance under ANCOVA analysis
- CDR Clinical Dementia Rating scale, CDR-SB CDR-Sum of Boxes, BDS-ADL Blessed Dementia Scale-Activities of Daily Living, SBT Short Blessed Test, MMSE Mini-Mental State Examination
